Ventolin Expectorant Adverse Reactions

As the combination product contains salbutamol and guaifenesin, the type and severity of adverse reactions associated with each of the components may be expected. The adverse reaction profile is derived from the individual components since there are limited clinical and post marketing reports available for the combination product.
Adverse reactions are listed as follows by system organ class and frequency. Frequencies are defined as: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000) and very rare (<1/10,000) including isolated reports. Very common and common reactions were generally determined from clinical trial data. Rare and very rare reactions were generally determined from spontaneous data.
Salbutamol: Immune system disorders: Very rare: Hypersensitivity reactions including angioedema, urticaria, bronchospasm, hypotension and collapse.
Metabolism and nutrition disorders: Rare: Hypokalaemia.
Potentially serious hypokalaemia may result from beta₂-agonist therapy.
Nervous system disorders: Very common: Tremor. Common: Headache. Very rare: Hyperactivity.
Cardiac disorders: Common: Tachycardia, palpitations. Rare: Cardiac arrhythmias including atrial fibrillation, supraventricular tachycardia and extrasystoles.
Vascular disorders: Rare: Peripheral vasodilatation.
Musculoskeletal and connective tissue disorders: Common: Muscle cramps. Very rare: Feeling of muscle tension.
Guaifenesin: Immune system disorders: Unknown: Hypersensitivity and allergic reactions including anaphylactic reactions, angioedema, rash, urticaria and dyspnoea.
Gastrointestinal disorders: Unknown: Nausea, vomiting, abdominal discomfort.